ASC Biosciences

OMSCs Differentiate into Cartilage

Jan 12, 2024By Scott Brovsky
Scott Brovsky

ASC Bio's OMSCs (Omnipotent Stem Cells) differentiate into many different cell types in vitro. We do this by treating the adherent OMSCs with logarithmic doses of dexamethason, from 10-10 M to 10-6 M.  Of course, 0 M dexamethasone is the control  One of the cell types that the OMSCs differentiate into is cartilage. However, what is interesting is that we see different morphologies of cartilage. At 10-6 M dexamethasone we see this:

chondrocytes with surrounding fibroblast-like cells
These are chondrocytes with surrounding fibroblast-like cells.

But at 10-9 M dexamethasone, we see this morphology:

These are chondrocytes but appear not to have any surrounding cells.
These are chondrocytes but appear not to have any surrounding cells.

It is possible that these are 2 different types of cartilage. The top could be fibrocartilage while the bottom would be articular chondrocytes. Further development in regrowing cartilage at ASC Bio is ongoing.